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HMGB1, a ligand of TLR4, can shuttle between the nucleus and cytoplasm

Funding This study was supported by grants from the National Natural Science Foundation of China (Grant numbers: 81971271 and 81971253), the Zhejiang Provincial Key Research and Development Programme (Grant number: 2021C03107), the Leading Talent of Scientific and Technological Innovation - 'Ten Thousand Talents Programme' of Zhejiang Province (Grant number: 2021R52016), the Zhejiang Provincial Natural Science Foundation (Grant number: LQ20H090013), the Programme from the Health and Family Planning Commission of Zhejiang Province (Grant number: 2020KY548) and Zhong yuan Technological Innovation leading Talents (Grant number: 204200510019)

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a second therapy e.g., prophylactic or therapeutic agent the therapies are administered to a subject in a sequence and within a time interval such that the therapy of the invention can act together with the other agent to provide an increased benefit than if they were administered otherwise

Vitamin B12 deficiency is one of the most common nutritional causes of peripheral neuropathy

Charting a dynamic DNA methylation landscape of the human genome